Did you know that oral spray Vitum-B12 can be as effective as intramuscular injections in treating anemia?

Vitum-B12 spray is used as a sublingual form of vitamin B12, and this is therapeutically as effective as oral administration of vitamin B12 (1). Studies have shown that using oral doses of vitamin B12 (1000 mcg and 2000 mcg) were as effective as intramuscular administration in achieving haematological and neurological responses (2).


A study demonstrated that oral B12 supplementation of 2000mcg daily for 4 months for patients with Vitamin B12 deficiency increased hematocrit levels, which is statistically significant in comparison to levels before treatment (3).

Another study on patients with megaloblastic anaemia due to cobalamin deficiency conducted for 3 months have demonstrated that vitamin B12 oral administration of 1000mcg daily for 10 days then followed by once a week for 4 weeks, and after that, once a month significantly improved haematological parameters. Increase in haemoglobin levels (Hbg), white blood cell count (WBC) and mean platelet count was recorded. In addition, mean corpuscular volume (MCV) was decreased (4).


This evidence suggests that Vitum-B12 oral spray can be used to improve haematological parameters, such as increased hematocrit levels at the dose 1000 mcg and 2000 mcg (equivalent to 8 sprays and 16 sprays of Vitum- B12 ) a day. It seems that in order to achieve a positive haematological outcome, daily administration of vitamin B12 should be carried out for 3-4 months.



  1. Sharabi A, Cohen E, Sulkes J, Garty M. Replacement therapy for vitamin B12 deficiency : comparison between the sublingual and oral route. BJCP [Internet]. 2003;635–8. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884303/
  2. Josep Vidal-Alaball1, Christopher Butler2, Rebecca Cannings-John2 AG, Kerry Hood2, Andrew McCaddon4, Ian McDowell5 and AP. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. Cochrane database [Internet]. 2016;(3). Available from: https://www.ncbi.nlm.nih.gov/pubmed/22650964
  3. Kuzminski AM, Del Giacco EJ, Allen RH, Stabler SP LJ. Effective Treatment of Cobalamin Deficiency With Oral Cobalamin. Blood [Internet]. 1998;92(4):1191–8. Available from: https://www.ncbi.nlm.nih.gov/pubmed/9694707
  4. Bolaman Z, Kadikoylu G, Yukselen V, Yavasoglu I, Barutca S ST. Oral versus intramuscular cobalamin treatment in megaloblastic anaemia: a single-center, prospective, randomised, open-label study. Clin Ther [Internet]. 2003; Available from: https://www.ncbi.nlm.nih.gov/pubmed/14749150


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